KMID : 0032220230350010061
|
|
Annals of Dermatology 2023 Volume.35 No. 1 p.61 ~ p.65
|
|
Case Report of a Novel Association between Anti-p200 Pemphigoid and Acquired Haemophilia A
|
|
Koh Xuan Qi
Tan Kong Bing Schmidt Enno Zillikens Detlef Chandran Nisha Suyien
|
|
Abstract
|
|
|
Anti-p200 pemphigoid is an uncommon subepidermal autoimmune bullous disease that, unlike many other autoimmune bullous diseases, has not previously been associated with hematological diseases. The diagnosis of anti-p200 pemphigoid in a patient with congruent clinical features requires the demonstration of subepidermal blistering, with linear deposition of immunoglobulin (Ig) G and/or C3 at the dermoepidermal junction on direct immunofluorescence, and a floor-binding pattern on indirect immunofluorescence. In addition, the detection of antibodies against p200 antigen via immunoblotting is ideal but not readily accessible in many facilities, leading to a potential under-recognition and under-diagnosis of this condition. In this case report, we describe a 53-year-old gentleman with recently diagnosed acquired hemophilia A who developed a concurrent vesiculobullous eruption and was evaluated to have anti-p200 pemphigoid. Both of his conditions were controlled with immunosuppression via prednisolone and cyclophosphamide. While we acknowledge the contemporaneous occurrence of both diseases in this patient may be a mere coincidence, it is important to recognize the possibility of this association given the potential clinical significance. Whether the activity of one disease parallels the other will require further evaluation.
|
|
KEYWORD
|
|
Blister, Dermatoses, Factor VIII, Hemophilia, Pemphigoid
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|